Our AffiAB® Goat Anti-OCLN Polyclonal IgG Antibody is a highly specific, validated reagent excellent for Western blotting applications. It specifically binds to OCLN and offers reliable results in a range of sample matrices.
The AffiAB® Goat Anti-OCLN Polyclonal IgG Antibody is an antibody specifically designed to target and detect the occludin protein. Occludin is a tight junction protein that plays a crucial role in the formation and maintenance of epithelial and endothelial cell barriers.
This polyclonal antibody is produced by immunizing goats with purified occludin protein or a specific peptide sequence derived from occludin. After immunization, the antibody is purified from goat serum to ensure high specificity and quality.
The AffiAB® Goat Anti-OCLN Polyclonal IgG Antibody is widely used in research applications to investigate the expression, distribution, and function of occludin in various biological systems. Occludin is a key component of tight junctions, which are specialized protein complexes that seal the gaps between adjacent cells, regulating the paracellular transport of ions, solutes, and macromolecules. By targeting occludin, researchers can examine its role in epithelial and endothelial barrier function, cell signaling, cell migration, and other cellular processes.
This antibody can be utilized in techniques such as Western blotting, immunohistochemistry, immunofluorescence, and immunoprecipitation to detect and analyze the expression and localization of occludin in different tissues and cell types. It allows researchers to investigate the impact of occludin in various physiological and pathological conditions, including barrier dysfunction, inflammation, cancer metastasis, and infectious diseases.
It is important to note that the AffiAB® Goat Anti-OCLN Polyclonal IgG Antibody specifically targets occludin and may not cross-react with other proteins. Researchers should validate the antibody's performance and specificity for their specific experimental conditions.
In summary, the AffiAB® Goat Anti-OCLN Polyclonal IgG Antibody is a valuable tool for studying the role of occludin in cell barrier function and related processes. It provides insights into the molecular mechanisms underlying tight junction dynamics and has implications for understanding various physiological and pathological conditions associated with disrupted barrier integrity.