dsRNA Antibodies: Gold Standard for Detection & QC

Double-stranded RNA (dsRNA) plays a central role in the biology of viruses and host defense mechanisms. Whether you're studying viral replication, immune activation, or RNA interference (RNAi), detecting and characterizing dsRNA with high precision is essential. That’s where AffiAB® Anti-dsRNA Monoclonal Antibodies come into play.

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🔍 Why dsRNA Detection Matters

In many viral infections, dsRNA is produced as a replication intermediate, making it a reliable biomarker of infection. It is also recognized by pattern recognition receptors like RIG-I, MDA5, and TLR3, triggering strong innate immune responses. Detecting dsRNA in biological samples helps researchers understand virus-host interactions, validate antiviral treatments, and study immune signaling pathways.

🧪 Meet the AffiAB® Anti-dsRNA Collection

AffiGEN’s AffiAB® line includes a comprehensive selection of monoclonal antibodies specifically designed for dsRNA detection in various experimental contexts.

🧬 AffiAB® Anti-dsRNA Monoclonal Antibody [J2]: AFG-JBS-0002

A gold standard in dsRNA research, J2 offers exceptional sensitivity and specificity.
Isotype: Mouse IgG2a, κ
Applications: ELISA, IF, IHC, WB

🧬 AffiAB® Anti-dsRNA Monoclonal Antibody [J5]: AFG-JBS-0003

A clone similar to J2 but targeting slightly different epitopes for confirmation or combination use.
Isotype: Mouse IgG2b, κ

🧬 AffiAB® Anti-dsRNA Monoclonal Antibody [K1]: AFG-JBS-0004

An excellent alternative clone for detecting longer dsRNA segments.
Isotype: Mouse IgG2a, κ

🧬 AffiAB® Anti-dsRNA Monoclonal Antibody [K2]: AFG-JBS-0005

A unique IgM isotype antibody for detecting dsRNA in formats requiring strong avidity.
Isotype: Mouse IgM

📦 AffiAB® dsRNA Antibody Panel (J2, J5, K1):  AFG-JBS-0006 

A ready-to-use panel for comprehensive detection and cross-validation in complex samples.

✅ Positive Control Included

To ensure the highest assay reliability, AffiGEN also offers a 142 bp synthetic dsRNA positive control AFG-JBS-0007 – an essential tool for validating antibody performance and assay sensitivity.

🔬 Applications Across Research Fields

• Virology: Detect replication intermediates in RNA virus-infected cells

• Immunology: Study dsRNA sensing pathways and innate immunity

• RNA Therapeutics: Validate delivery and silencing efficiency in RNAi experiments

• Oncology & Stress Response: Investigate dsRNA accumulation under stress or in cancer models

💡 Why Choose AffiAB® Anti-dsRNA Antibodies?

• ✅ Highly specific to dsRNA, with minimal cross-reactivity

• 🔬 Validated for ELISA, IF, IHC, and WB

• 📊 Ensures reproducible and reliable results

• 🧪 Designed for a wide range of biological systems and applications

• 🧫 Backed by a positive control for easy assay validation

🧷 Ready to Upgrade Your Detection?

AffiGEN's AffiAB® Anti-dsRNA antibody collection empowers researchers with the confidence, precision, and consistency they need for dsRNA-focused studies. Whether you're screening viral infections or probing the innate immune landscape, this toolbox is your go-to solution.